DUPIXENT® (dupilumab) Injection Instructions & Support (2024)

REAL PATIENTS DISCUSS TAKING DUPIXENT

Important Safety Information
and Indications

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

• have eye problems.
• have a parasitic (helminth) infection.
• are scheduled to receive any vaccinations. You should not receive a “live vaccine” right before and during treatment with DUPIXENT.
• are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • A pregnancy registry for women who take DUPIXENT during pregnancy collects information about the health of you and your baby. To enroll or get more information call 1-877-311-8972or go to https://mothertobaby.org/ongoing-study/dupixent/.
• are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines; have asthma and use an asthma medicine; or have atopic dermatitis, chronic rhinosinusitis with nasal polyposis, eosinophilic esophagitis, or prurigo nodularis and also have asthma. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

• Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms: breathing problems or wheezing, swelling of the face, lips, mouth, tongue or throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives, joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea or vomiting, or cramps in your stomach-area.
• Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision. Your healthcare provider may send you to an ophthalmologist for an exam if needed.
• Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have: rash, chest pain, worsening shortness of breath, a feeling of pins and needles or numbness of your arms or legs, or persistent fever.
• Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.

The most common side effects include:

• Eczema: injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, dry eye, cold sores in your mouth or on your lips, and high count of a certain white blood cell (eosinophilia).
• Asthma: injection site reactions, high count of a certain white blood cell (eosinophilia), pain in the throat (oropharyngeal pain), and parasitic (helminth) infections.
• Chronic Rhinosinusitis with Nasal Polyposis: injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, high count of a certain white blood cell (eosinophilia), gastritis, joint pain (arthralgia), trouble sleeping (insomnia), and toothache.
• Eosinophilic Esophagitis: injection site reactions, upper respiratory tract infections, cold sores in your mouth or on your lips, and joint pain (arthralgia).
• Prurigo Nodularis: eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, herpes virus infections, common cold symptoms (nasopharyngitis), dizziness, muscle pain, and diarrhea.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider. In children 12 years of age and older, it’s recommended DUPIXENT be administered by or under supervision of an adult. In children 6 months to less than 12 years of age, DUPIXENT should be given by a caregiver.

Please see accompanying adjacent links for full Prescribing Information including Patient Information.

Indications

DUPIXENT is a prescription medicine used:

• to treat adults and children 6 months of age and older with moderate-to-severe eczema (atopic dermatitis or AD) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 months of age.
• with other asthma medicines for the maintenance treatment of moderate-to-severe eosinophilic or oral steroid dependent asthma in adults and children 6 years of age and older whose asthma is not controlled with their current asthma medicines. DUPIXENT helps prevent severe asthma attacks (exacerbations) and can improve your breathing. DUPIXENT may also help reduce the amount of oral corticosteroids you need while preventing severe asthma attacks and improving your breathing. DUPIXENT is not used to treat sudden breathing problems. It is not known if DUPIXENT is safe and effective in children with asthma under 6 years of age.
• with other medicines for the maintenance treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP) in adults whose disease is not controlled. It is not known if DUPIXENT is safe and effective in children with chronic rhinosinusitis with nasal polyposis under 18 years of age.
• to treat adults and children 1 year of age and older with eosinophilic esophagitis (EoE), who weigh at least 33 pounds (15 kg). It is not known if DUPIXENT is safe and effective in children with eosinophilic esophagitis under 1 year of age, or who weigh less than 33 pounds (15 kg).
• to treat adults with prurigo nodularis (PN). It is not known if DUPIXENT is safe and effective in children with prurigo nodularis under 18 years of age.

OUR SUPPORT TEAM CAN HELP

I grew up in a very small town—one stop light, if you blink you might miss it. Very quaint. The small-town environment lends to the type of work that I do, more one-on-one with our patients.

My name is Shari and I’m a registered nurse with DUPIXENT MyWay.

I chose to be a nurse because I wanted to help people, and I believe that people should be in service to others.

Being a nurse for DUPIXENT MyWay is very rewarding. I really enjoy the patient interaction. I’m ready to make a difference. I’m ready to help our patients to have the confidence to proceed with their journey.

Our nurses work remotely from our homes. So, we step into our offices, we’re going into a nice relaxing environment.

When our patients call in, they get to speak to a real person, a experienced clinician who can provide them support along their journey.

We provide general product support and education, as well as supplemental injection training, and injection and refill reminder calls.

Every day is different depending on the type of calls that we have. Some of the common questions we get: “How much is it going to cost me?” “When will I get started?” “How do I take my DUPIXENT injections when I’m traveling?”

We have multiple resources available for patients. We have the ability to send out package inserts that include all the important safety information for DUPIXENT. For patients wanting a copay card, they can access that by visiting our product website at DUPIXENT.com.

One of my favorite parts of providing nursing care to our patients is being able to walk them through their journey, hold their hand through the process, just to give them confidence along the way and we always want them to know that they have our support.

LAURIE, Field Nurse

I’m Laurie. I’m a registered nurse with DUPIXENT MyWay. I’ve been with DUPIXENT MyWay since the very beginning.

I give supplemental injection training to the patient and the patient’s caregiver.

When I was very young, I knew that I wanted to be a nurse. I wanted to go out and make a difference and help people.

When I get the order for the patient, I get really excited. I travel to see the patients—sometimes for hours. I make sure that I gather all of the things that I may need to help the experienced person, and then the person that’s never even touched a needle.

I think it’s very important for me as a nurse to go and teach these patients. Not only to teach them how to give themselves the medicine, but also to just come and give them encouragement, and show them kindness and patience.

When I go to see the patient, I can’t wait to travel, no matter how far it is. I have a training kit that has a training syringe in it. And that helps us so that we can practice before we do the real thing.

I can’t wait to go and meet them, and see where they are in their life, and be excited for them.

I help them to relax. Sometimes they can just take a deep breath, we’ll go slow, think about their favorite place, think about something that reminds them and makes them happy and calms them down.

I went to this patient’s house and he seemed very standoffish. You could tell that the patient was just not comfortable. He was anxious, he wouldn’t give me eye contact. So, I asked the parents, “would it be OK if I just come back the next day?"

I think it’s very important to just be patient. Make it into their routine and let them go at their own pace. We have time. They have set aside this time for us to learn. And for me to teach.

Sometimes at the end of the training, I’ll get some questions about, “You know, we did great today, but what else? What if when you leave, I don’t know what to do and it’s time for me to give myself my injection again?” I can refer the patient to the DUPIXENT website for more resources and there’s also a Nurse Educator phone number.

I like to go out and do this job. It’s just really neat. It’s neat to go in and get to know people.

DUP.23.04.0076

FEELING UNCERTAIN?

Need help keeping thoughts from getting in your way? You can change your perspective to help stay the course.

When you’re thinking about doing something you consider difficult…or that is just…out of your comfort zone, it’s not uncommon to feel nervous or uneasy.

But…what happens when those feelings lead to thoughts like, “I’ll never be able to do this” or “It’s just too hard?”

Thoughts like these can be overwhelming, and may not be helpful.

In fact, unhelpful thoughts can negatively affect what you’re trying to accomplish…they may even keep you from trying it at all.

So, how can you help keep these thoughts from getting in your way?

Remember that thoughts are not always facts.

If you change how you look at them, you may be able to take their power away.

See if you can do that by changing your perspective and looking at this situation a little differently.

Try to focus on what you are trying to do and why.

What’s the reason for doing it?

Think about another difficult situation you’ve overcome.

How did that situation affect you?

Recognize that you don’t have to take on challenges alone.

Who or what can support you in this situation?

Take time to get familiar with the task at hand.

What resources can you use to help guide you?

Taking this different view might just be what’s needed to help you stay the course and give this thing a try!

Of course, even after you decide to do it, nervous feelings and unhelpful thoughts might still come up…but that’s OK!

Just remind yourself:

Thoughts are not always facts.

And if you can change how you view them, you may be able to change how you feel and help keep yourself on track.

Before long—and with proper training and practice—you can start feeling more confident to tackle the challenge, time and again.

You may even notice that what you saw before as unfamiliar and intimidating might not be as difficult to navigate as you thought.

So…let’s do this!

See if you can change your thoughts to help build your confidence and work toward your goal.

Whenever you are facing a situation that’s making you feel nervous, remember:

You have the power to change your thoughts and look at things from a more encouraging perspective.

• Remember to keep your reason for doing this in mind to help guide you along the way.
• Tell yourself that you’ve tackled challenges before. You can do it again.
• Rely on resources to help you through difficult situations. Feeling supported can build confidence.
• Focus on what you want to accomplish and what you hope to gain.

Watch this video whenever you need a reminder of how you already have and can continue to tackle new challenges.

Have questions? Call aDUPIXENT MyWay®Nurse Educator at 1-844-DUPIXENT (1-844-387-4936), option 1.

DUP.21.10.0204

MINDFUL BREATHING

Transcript

Let’s take a second to get situated before we begin our breathing exercise.

Find a spot where you can be still and quiet. Get into a comfortable position. This can be seated, standing, or laying down. Pause for just a moment before you begin.

Now, close your eyes and settle your mind.

Focus on your body relaxing as you settle into position. Relax your muscles; start with your toes, work upward to your arms and then your head. Transition your focus to your breath.

Slowly take a deep breath. Let your stomach expand [pause], and now your rib cage, and your chest. Pause for just a moment.

Exhale at the same pace as the inhale. Allow the breath to come steadily out of your nose until your lungs are completely empty.

Pay attention when you breathe in. First your stomach rises, then your rib cage, finally your chest. Notice each of them fall as you breathe out: chest, rib cage, stomach.

Feel your body respond as you continue to breathe.

This can be done for as long as you like. You can repeat this any time you are feeling anxious to help calm yourself.